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ANTI-CCR5 MONOCLONAL ANTIBODY-BASED COMPOSITIONS AND METHODS
ANTI-CCR5 MONOCLONAL ANTIBODY-BASED COMPOSITIONS AND METHODS
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机译:基于抗CCR5单克隆抗体的组合物和方法
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摘要
This invention provides humanized IgG4 monoclonal antibodies having the light and heavy chain variable region amino acid sequences of PRO 140, wherein the antibody comprises (i) a heavy chain modification that inhibits half antibody formation, (ii) a heavy chain modification that increases the antibody's terminal half-life, and, optionally, (iii) a heavy chain modification that lowers the antibody's effector function. This invention also provides a related humanized IgG2/IgG4 monoclonal fusion antibody. This invention further provides related nucleic acid molecules; recombinant vectors; recombinant AAV particles; pharmaceutical compositions; prophylactic and therapeutic methods for addressing HIV-1 infection, SARS-CoV-2 infection, and CCR5-mediated disorders; and kits for performing these methods.
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