FLUORESCENT RAPID NEUTRALIZATION ASSAY FOR VIRAL INFECTIONS

摘要

The present disclosure describes, in part, a fluorescent rapid neutralization assay for viral infections. A reporter system for detecting SARS-CoV-23CLpro in a sample is provided as well as methods of using the system to detect the presence of virus, to detect the presence of the viral 3CLpro protease and to screen for agents capable of inhibiting the 3CLpro protease. In some embodiments, the viral infection comprises SARS-CoV-2.