NOVEL COMPOUNDS CAPABLE OF ANTAGONIZING ISLET AMYLOID POLYPEPTIDE(IAPP) INDUCED BETA-CELL DAMAGE AND IMPAIRED GLUCOSE TOLERANCE

摘要

A molecule that specifically binds to human islet amyloid polypeptide (hIAPP), also known as amylin, in particular islet amyloid polypeptide (IAPP), a condition typically associated with type 2 diabetes (T2D) induced β-cell injury and impaired glucose Human-derived antibodies for antagonizing resistance as well as fragments, derivatives and variants thereof are described.