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Interactions of human islet amyloid polypeptide with lipid structure of different curvatures

机译:人胰岛淀粉样多肽与不同曲率脂质结构的相互作用

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摘要

Curvature is one of the most important features of lipid membranes in living cells,which significantly influences the structure of lipid membranes and their interaction with proteins.Taken the human islet amyloid polypeptide(h IAPP),an important protein related to the pathogenesis of type II diabetes,as an example,we performed molecular dynamics(MD)simulations to study the interaction between the protein and the lipid structures with varied curvatures.We found that the lipids in the high curvature membrane pack loosely with high mobility.The h IAPP initially forms H-bonds with the membrane surface that anchored the protein,and then inserts into the membrane through the hydrophobic interactions between the residues and the hydrophobic tails of the lipids.h IAPP can insert into the membrane more deeply with a larger curvature and with a stronger binding strength.Our result provided important insights into the mechanism of the membrane curvature-dependent property of proteins with molecular details.

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  • 来源
    《力学快报(英文版)》 |2020年第6期|412-418|共7页
  • 作者单位

    Biomechanics and Biomaterials Laboratory Department of Applied Mechanics Beijing Institute of Technology Beijing 100081 China;

    Biomechanics and Biomaterials Laboratory Department of Applied Mechanics Beijing Institute of Technology Beijing 100081 China;

    Institute of Applied Mechanics Department of Engineering Mechanics Zhejiang University Hangzhou 310027 China;

    Biomechanics and Biomaterials Laboratory Department of Applied Mechanics Beijing Institute of Technology Beijing 100081 China;

    Institute of Applied Mechanics Department of Engineering Mechanics Zhejiang University Hangzhou 310027 China;

    Institute of Applied Mechanics Department of Engineering Mechanics Zhejiang University Hangzhou 310027 China;

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  • 入库时间 2022-08-19 04:44:42
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