METHOD FOR INDUCING NEUTRALIZING ANTIBODY BASED ON CELL MEMBRANE TO DISPLAY CORONAVIRUS IMMUNOGEN

摘要

Disclosed is a method for inducing a neutralizing antibody based on a cell membrane to display a coronavirus immunogen. Specifically, provided are a cell that displays novel coronavirus SARS-CoV-2 spike protein S on the cell membrane surface thereof, a vaccine or a vaccine combination against novel coronavirus SARS-CoV-2 containing the cell, the use of the cell in the preparation of a vaccine for preventing or treating the novel coronavirus SARS-CoV-2, and a preparation method therefor. The cells and vaccines can efficiently activate B cells in vivo, induce neutralizing antibody responses, and have a wide application prospect in preventing and reducing novel coronavirus infection.