METHOD FOR INDUCING ANTI-NOVEL CORONAVIRUS NEUTRALIZING ANTIBODY USING RECEPTOR RECOGNITION DOMAIN

摘要

A method for inducing an anti-novel coronavirus neutralizing antibody using a receptor recognition domain is provided. Specifically, an immunogenic peptide for novel coronavirus SARS-CoV-2 is provided, comprising an RBD region of SARS-CoV-2 virus spike protein S or a cysteine-modified RBD region, and encoding a nucleotide molecule, a vector containing the nucleotide molecule, and a host cell. A vaccine for novel coronavirus SARS-CoV-2, preparation and application thereof are also provided. The vaccine is safe, can continuously produce high-potency neutralizing antibodies, and can be used in the prevention and/or treatment of novel coronavirus infections and symptoms thereof.