Lipid nanoparticles of antisense oligonucleotides suppressing Bcl-2 and their preparation method

摘要

The present invention discloses antisense oligonucleotide lipid nanoparticles that suppress bcl-2 and a method for preparing the same. The lipid nanoparticles are prepared by coating an antisense oligonucleotide with a membrane material, and the nucleotide sequence is 5′-TCT CCC AGC GTG CGC CAT-3 ′ or 5 ′ UCU CCC AGC GTG CGC CAU 3 ′. .