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Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency
Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency
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机译:糖皮质激素受体拮抗剂与糖皮质激素组合使用以治疗肾上腺素不足
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摘要
This invention provides for a method of treating secondary adrenal insufficiency by co-administrating therapeutically effective amounts of a glucocorticoid and a glucocorticoid receptor antagonist to the patient in need thereof. In some embodiments, the method includes the proviso that the patient not be otherwise in need of treatment with a glucocorticoid and a glucocorticoid receptor antagonist. The treatment method can increase the patient's morning or basal cortisol level to at least about 12 μg/dL or a standard control level, and in turn, expedite significantly the recovery of the HPA axis. The method provided herein can improve health outcomes and life-threatening complications associated with secondary adrenal insufficiency.
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