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Thioester prodrugs of macrocycles as inhibitors of histone deacetylases
Thioester prodrugs of macrocycles as inhibitors of histone deacetylases
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机译:硫代酯前药作为组蛋白脱乙酰酶的抑制剂
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摘要
The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.;
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