METHOD FOR PREPARING LANINAMIVIR OCTANOATE INTERMEDIATE BY MEANS OF ONE-POT SYNTHESIS

摘要

The present invention relates to the technical field of medicine synthesis, and specifically relates to a method for preparing a laninamivir octanoate intermediate by means of one-pot synthesis. The method for preparing a laninamivir octanoate intermediate by means of one-pot synthesis comprises: subjecting a compound as represented by formula (4) to a reaction in the presence of R1OH, NaH and (R1O)2CO to obtain a compound as represented by formula (5), wherein R1 is benzyl, substituted benzyl, or allyl. A laninamivir octanoate intermediate compound (5) is innovatively synthesized from a compound (4) by means of using one-pot synthesis; the reaction is gentle and rapid, and the next-step reaction can be carried out after simple post-treatment; energy consumption is saved, the pollution is reduced, operation is simple and the cost is low, such that the method is suitable for industrial production. The laninamivir octanoate intermediate compound (5) prepared by means of using one-pot synthesis has a yield of at least 87%.