NANOPARTICLES AS BIORESORBABLE AND RADIOPAQUE ACTIVE-INGREDIENT CARRIERS FOR THE THERAPY OF CANCERS OF THE PANCREAS

摘要

Nanoparticles according to the invention as bioresorbable and radiopaque active-ingredient carriers for the therapy of cancers of the pancreas are characterized in that they consist of tungsten or an alloy of at least 38% by mass of tungsten and at least one further element of the elements molybdenum, rhenium, tantalum, niobium and hafnium. Bound on the outer surface or on a coating formed on the outer surface and comprising a biodegradable substance are molecules of an active ingredient having proven effectiveness against malignant tumor cells of ductal adenocarcinomas and/or PanNETs, such that the binding of said active-ingredient molecules (W) is effected by means of first linker molecules (L1) which are covalently bonded both to the active-ingredient molecules (W) and to the particle surface or coating (2).