COMPOSITION FOR INDUCING DIRECT CROSS DIFFERENTIATION OF SOMATIC CELL INTO MOTOR NEURON, AND METHOD FOR USING SAME

摘要

The present invention relates to: a composition for inducing direct cross differentiation of a somatic cell into a motor neuron; a motor neuron induced for direct cross differentiation by introducing the composition to a somatic cell; a pharmaceutical composition for preventing or treating a nervous system disorder and damage; a cell therapy agent; a composition for screening a drug for preventing or treating a nervous system disorder and damage; and a 3D printing biomaterial composition for creating artificial tissue. If a composition of one aspect is used, differentiation of a somatic cell into a motor neuron can be efficiently induced without involving a pluripotency stage of an induced pluripotent stem cell, through expression of a direct cross differentiation inducer, and, thus, effective prevention and treatment of a nervous system disorder and damage are possible using the composition. Also, an induced motor neuron of one aspect may be widely utilized in the field of regenerative medicine, as the induced motor neuron can be used as the 3D printing biomaterial composition for creating artificial tissue for treatment, which can treat a nervous system damage and disorder conventionally known as an intractable disease.