Compositions for Inducing Cell Growth and Differentiation and Methods of Using Same.

摘要

Compositions, including, for example, soluble Ryk polypeptides and Wnt polypeptides, that induce cell growth and/or differentiation, including, for example, neurite outgrowth and hematopoietic cell proliferation and differentiation, are provided. Methods of using such compositions also are provided, including, for example, methods of using such compositions to induce neurite outgrowth (e.g., in a subject having a neuronal disorder). In addition, methods to identify agents that alter Ryk mediated signal transduction in a cell are provided.