Fibronectin binding peptides for use in the diagnosis and treatment of tumors or fibrosis

摘要

Problem to be solved: to provide a new and improved means for targeting the tissue associated with an increase in FN content, preferably fibrous tissue with increased FN content and organs that accumulate cancer tissue or injected peptide, to target the diagnostic and / or therapeutic means.The present invention comprisesA composition comprising at least one fibronectin binding polypeptide (Fnbp) bound to at least one diagnostic or therapeutic agentAt least one diagnosis or treatment includes a nucleic acid encoding a fusion polypeptide comprising at least one fibronectin binding polypeptide (Fnbp) bound to a polypeptide agent and such nucleic acidPreferably the corresponding recombination vector and host cells express the fused polypeptide.The present invention also relates to a part kit comprising at least one fibronectin binding polypeptide (Fnbp), at least one diagnostic agent or therapeutic drug, and one or more chemicals for binding fibronectin binding polypeptide (Fnbp) to a diagnostic agent or therapeutic agent in an optional manner.Further, the present invention contemplates the composition, nucleic acid, vectors, host cells and kits for use in therapeutic or prophylactic treatments of diseases, preferably cancer associated with abnormal fibronectin accumulation such as fibrosis or immune disorders.No selection