Fibronectin binding peptides for use in the diagnosis and treatment of tumors or fibrosis

摘要

The present invention provides a composition comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic agent or therapeutic agent, a composition comprising one or more fibronectin binding polypeptides (FnBP) linked to at least one diagnostic or therapeutic polypeptide preparation Nucleic acid, and a corresponding recombinant vector and host cell comprising said nucleic acid and preferably expressing said fusion polypeptide. The invention also encompasses a kit comprising at least one fibronectin binding polypeptide (FnBP), at least one diagnostic or therapeutic agent, and optionally at least one chemical agent for linking a fibronectin binding polypeptide (FnBP) to a diagnostic or therapeutic agent parts. The present invention also relates to such compositions, nucleic acids, vectors, host cells and kits for use in the therapeutic or prophylactic treatment of diseases, preferably diseases associated with abnormal fibronectin accumulation, such as cancer, fibrosis or immune disorders .