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ANTIGEN-BINDING MOLECULES CAPABLE OF BINDING CD3 AND CD137 BUT NOT SIMULTANEOUSLY
ANTIGEN-BINDING MOLECULES CAPABLE OF BINDING CD3 AND CD137 BUT NOT SIMULTANEOUSLY
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机译:能够结合CD3和CD137但不同时结合CD3和CD137的抗原结合分子
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摘要
The present invention relates to antigen-binding molecules binding to CD3 and CD137 (4-1BB); compositions comprising the antigen-binding molecule; and methods of using the same. The present invention provides antigen-binding molecules comprising: an antibody variable region that is capable of binding to CD3 and CD137 (4-1BB), but does not bind to CD3 and CD137 at the same time; and a variable region binding to a third antigen different from CD3 and CD137. Such antigen binding molecules exhibit enhanced T-cell dependent cytotoxity activity induced by these antigen-binding molecules through binding to the three different antigens.
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