LACTOCOCCUS LACTIS EXPRESSION SYSTEM FOR DELIVERING PROTEINS EFFICACIOUS FOR THE TREATMENT OF EPITHELIAL BARRIER FUNCTION DISORDERS

摘要

The disclosure relates to live biotherapeutic products, probiotics, and therapeutic composition comprising said probiotics having therapeutic proteins, and methods of using them to treat various human diseases. In particular aspects, the disclosure provides such compositions comprising strains of the Lactococcus lacus bacterium within which said therapeutic protein are present. The disclosed pharmaceutical compositions are useful for treating gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity, especially, for treating or preventing various types of mucositis.