- Gold nanoparticle-aptamer conjugates-based antibody delivery system and preparation method thereof

摘要

The present invention relates to an antibody delivery system based on a gold nanoparticle-aptamer conjugate and a method for preparing the same, wherein the antibody delivery system according to the present invention comprises an IgG Fc domain-specific aptamer or a FITC-specific aptamer to gold nanoparticles. It is bound, and by specifically binding the antibody to be delivered to the aptamer, the antibody can be effectively delivered to the nucleus and cytoplasm of the cell as well as to the mitochondria. In addition, by using gold nanoparticles with very little cytotoxicity, they are not only harmless to the human body, but also reflect light at various wavelengths to easily check their location in the cell, which can be usefully used for diagnosis or treatment of diseases. it is expected that it will be possible