GOLD NANOPARTICLE-APTAMER CONJUGATE-BASED ANTIBODY DELIVERY SYSTEM, AND PREPARATION METHOD THEREOF

摘要

The present invention relates to an antibody carrier based on a gold nanoparticle (AuNP)-aptamer conjugate and a method of preparing the same. The antibody carrier according to the present invention is prepared by binding of an immunoglobulin G (IgG) Fc domain-specific aptamer or a fluorescein isothiocyanate (FITC)-specific aptamer to AuNP, and may effectively deliver an antibody into the cell nucleus, the cytoplasm and mitochondria by specific binding of the antibody to be delivered to the aptamer. In addition, since the AuNP having very low cytotoxicity is used, the antibody carrier is not only harmless to the human body, but may also detect a location in cells easily by reflecting light at various wavelengths, and therefore, it is expected to be effectively used in diagnosis or treatment of a disease.