N1-(4-(5-(CYCLOPROPYLMETHYL)-1-METHYL-1H-PYRAZOLE-4-YL)PYRIDINE-2-YL)CYCLOHEXANE-1,4-DIAMINE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF CK1 AND/OR IRAK1 FOR THE TREATMENT OF CANCER

摘要

FIELD: medicine.;SUBSTANCE: present invention provides for pyrazole derivatives of the formula (I) and, in particular, N1-(4-(5-(cyclopropylmethyl)-1-methyl-1h-pyrazole-4-yl)pyridine-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as inhibitors of casein kinase 1 (hereinafter – CK1) and/or interleukin-1-associated kinase-1 receptor (hereinafter – IRAK1) for the treatment of cancer, inflammatory and immune-mediated disorders.;EFFECT: obtaining N1-(4-(5-(cyclopropylmethyl)-1-methyl-1h-pyrazole-4-yl)pyridine-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as inhibitors of CK1 and/or IRAK1 for the treatment of cancer.;30 cl, 8 ex, 1 tbl, 1 dwg