首页> 外国专利> 12-c-3- Novel dihydroindeno12-cpyrazole-3-carboxamide derivatives and pharmaceutical composition for preventing or treating neurodevelopmental disorders or neurodegenerative diseases comprising the same

12-c-3- Novel dihydroindeno12-cpyrazole-3-carboxamide derivatives and pharmaceutical composition for preventing or treating neurodevelopmental disorders or neurodegenerative diseases comprising the same

机译:[12-C] -3-新的二氢吲哚酮[12-C]吡唑-3-甲酰胺衍生物和药物组合物用于预防或治疗包含相同的神经发育障碍或神经变性疾病

摘要

The present invention relates to a novel dihydroindeno[1,2-c]pyrazole-3-carboxamide derivative and a pharmaceutical composition for preventing or treating neurodevelopmental disorders or neurodegenerative diseases comprising the same as an active ingredient, It is possible to provide a compound useful as a composition for preventing or treating neurodevelopmental disorders or neurodegenerative diseases because of its excellent GSK3β inhibitory activity and excellent NFκB activity inhibition and Wnt/β-catenin signaling system activation effects in MeCP2-depleted cells.
机译:本发明涉及新型二氢吲唑-3-甲酰胺衍生物和用于预防或治疗与活性成分相同的神经发育疾病或神经变性疾病的药物组合物,可以提供有用的化合物 作为用于预防或治疗神经发育疾病或神经变性疾病的组合物,因为其优异的GSK3β抑制活性和优异的NFκB活性抑制和WNT /β-Catenin信号传导系统活化效应在MECP2耗尽的细胞中。

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