NLRP3 Composition comprising NLRP3 inflammasome inhibitor for prevention improvement or treatment of age-related periodontal diseases and method thereof

摘要

The present invention relates to a composition for preventing, improving or treating inflammasome-mediated senile periodontal disease using an NLRP3 inflammasome inhibitor, and a method thereof, and more particularly, the NLRP3 inflammasome inhibitor MCC950 activates caspase-1 It relates to a method for preventing or treating periodontal disease, characterized in that it effectively suppresses alveolar bone loss, which is representative of senile periodontal disease, by inhibiting the inflammatory cytokine interleukin-1beta secretion. The composition of the present invention has excellent specificity with respect to the drug action point and has no body toxicity, so it can be applied to mouthwash (gargle), toothpaste, ointment or injection for oral disease treatment.