Runx3 RUNX3 MODIFIED PROTEIN FOR PREVENTION OR TREATMENT OF CANCER

摘要

In the present invention, the mutant protein in which the 356th serine of Runx3 is substituted with alanine has improved the activity of maintaining the complex with Brd2 by 10 times or more compared to wild-type Runx3, and the apoptosis ability is improved in various cancer cell lines compared to wild-type Runx3. The effect was confirmed. Therefore, a mutant protein in which the 356th serine of the Runx3 protein of the present invention is substituted with an amino acid that cannot be phosphorylated by kinase, a polynucleotide encoding it, a vector containing the polynucleotide or by the vector The transformed virus or cell can be used as a therapeutic agent for various cancers.