Colonic expression of Runx3 protein and TGF-β1 and their correlation in patients with irritable bowel syndrome

摘要

Objective:To investigate the role of Runx3 protein and TGF-β1 in the pathogenesis of irritable bowel syndrome(IBS), as well as the correlation of these two proteins.Methods: Colonic tissue was collected from patients with IBS and normal persons. The colonic expression of Runx3 protein andTGF-β1 was detected with immunohistochemistry method. Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.Results: Compared with their counterparts, patients withIBS did not show any changes in the colonic expression of Runx3 protein andTGF-β1 (P>0.05). Interestingly, there was a significant correlation between Runx3 protein andTGF-β1 in patients withIBS(P<0.05).Conclusions:The role of Runx3 protein and TGF-β1 in the pathogenesis ofIBS remains to be further studied.