A MICROFLUIDIC DEVICE FOR INVESTIGATING INTERACTIONS OF SUBSTANCES WITH CELLS

摘要

The invention provides a microfluidic device for investigating an interaction of one or more substances with cells cultured therein, the microfluidic device comprising: one or more internal spaces including a vessel configured to contain a first fluid comprising the one or more substances; and a polymeric coating on walls of at least the vessel, wherein the polymeric coating comprises at least one cross-linked polymer chemically bonded to the walls and comprising a plurality of conjugating functional groups available for reaction, wherein polypeptide-containing macromolecules contacted with the polymeric coating in use are immobilised thereon by covalent bond formation with the conjugating functional groups, thereby adapting the walls for culturing cells.