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Methods for engineering allogeneic T cell to increase their persistence and/or engraftment into patients
Methods for engineering allogeneic T cell to increase their persistence and/or engraftment into patients
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机译:工程异构T细胞的方法将其持久性和/或植入增加到患者
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摘要
The present invention relates to methods for developing engineered immune cells such as T-cells for immunotherapy that have a higher potential of persistence and/or engraftment in host organism. IN particular, this method involves an inactivation of at least one gene involved in self/non self recognition, combined with a step of contact with at least one non-endogenous immunosuppressive polypeptide. The invention allows the possibility for a standard and affordable adoptive immunotherapy, whereby the risk of GvH is reduced.
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