Substituted n - 2 - (4-phenoxyppiperidin-1-yl) - 2 - (1,3-thiazol-5-yl) ethyl benzamide and N - 2 - (4-benzyloxpiperidin-1-yl) - 2 - (1,3-thiazol-5-yl)) Benzamide derivative P2X7 receptor antagonist

摘要

The present invention relates to novel substituted phenoxy and benzyloxypiperidine compounds of formula (I) having P2X7 receptor (P2X7) antagonist properties, pharmaceutical compositions comprising these compounds, chemical methods for preparing these compounds and animal It particularly relates to their use in the treatment or prevention of diseases associated with human P2X7 receptor activity. [Chemical 1]