The present disclosure may provide a system and method for using a viral respiratory infection detection device, a method comprising: obtaining a biological sample from a subject; preparing the biological sample for testing; placing at least a portion of the prepared biological sample into a sample port of a viral respiratory infection detection device thereby contacting a sample pad with the prepared biological sample thus initiating a first test strip and a second test strip, wherein the first testing strip is formed to detect the binding of a respiratory virus to a recombinant human receptor protein, wherein the second testing strip is formed to detect the binding of a specific respiratory virus to a specific recombinant spike glycoprotein; and analyzing the results of the first test strip and the second test strip.
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