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Method for treating glioblastoma or glioma with antibody constructs for EGFRVIII and CD3
Method for treating glioblastoma or glioma with antibody constructs for EGFRVIII and CD3
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机译:用抗体构建体处理胶质母细胞瘤或胶质瘤的方法,用于EGFRVIII和CD3
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摘要
The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human EGFRVIII on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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