FLT3-TARGETED CHIMERIC ANTIGEN RECEPTOR MODIFIED CELLS FOR TREATMENT OF FLT3-POSITIVE MALIGNANCIES

摘要

Provided are compositions comprising a population of autologous or allogeneic cells transduced by a nucleic acid molecule encoding a chimeric antigen receptor (CAR) specifically recognizes and binds FMS-like tyrosine kinase 3 (FLT3), methods of formulating preparing such CAR expressing cells and methods of use as anti-cancer agents.