REAL-TIME IN SITU MONITORING OF DRUG PRODUCT DEGRADATION USING WATER PROTON NMR

摘要

A method of using the relaxation rate (R1 and/or R2) of solvent NMR signal to assess whether drug products have undergone substantial chemical degradation during manufacturing, transport and/or storage. The monitoring can be performed under both static and flow conditions, in real-time and in a contact-free manner.