In one aspect, the present invention provides 2,4-dichloro-a- (3,4-dihydro-4-oxo-2 (1H) -quinazolinylidene) -β-oxo-benzenepropanenitrile, an optical or stereoisomer thereof, The present invention relates to a composition for blackening hair, preventing whitening of hair, preventing or improving melanin-lowering diseases, comprising an acceptable salt, hydrate or solvate thereof as an active ingredient. Aspects can provide consumers with new uses and benefits of 2,4-dichloro-a- (3,4-dihydro-4-oxo-2 (1H) -quinazolinylidene) -β-oxo-benzenepropanenitrile. And the development of related industries. [Selection] Figure 1
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