One aspect of the present invention relates to a composition containing, as an active ingredient, 2,4-dichloro-a-(3,4-dirydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo- benzenepropanenitrile, optical or stereoscopic isomers thereof, pharmaceutically acceptable salts thereof, hydrates thereof, or solvates thereof, for darkening hair color, preventing hair discoloration, and the prevention and treatment of melanin-reducing disease. According to the one aspect of the present invention, a novel use and effect of the 2,4-dichloro-a-(3,4-dirydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo- benzenepropanenitrile can be provided to consumers and related industries can be promoted.
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