COMPOSITIONS AND METHODS FOR MODULATING THE TRANSMISSION OF A LAIR SIGNAL

摘要

FIELD: medicine.;SUBSTANCE: invention relates to a fused protein containing an amino acid sequence according to SEQ ID NO:16, where the fused protein is an immunomodulatory agent that increases or enhances an immune function by inhibiting ligand binding to LAIR-1, thereby reducing LAIR-1 expression, ligand binding, cross-linking, signal transmission or a combination thereof. A pharmaceutical composition containing the specified fused protein is also proposed, which is intended to stimulate an immune response to inhibit the survival of malignant cells, or to stimulate an antitumor immune response to malignant cells, or to stimulate an immune response against bacterial infections. ;EFFECT: fused protein can be used to treat diseases such as ovarian cancer, lymphoma or bacterial infection.;19 cl, 25 dwg, 21 ex