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DELAYED RELEASE DRUG FORMULATION COMPRISING AN OUTERLAYER WITH AN ENZYMATICYALLY DEGRADABLE POLYMER, ITS COMPOSITION AND ITS METHOD OF MANUFACTURING
DELAYED RELEASE DRUG FORMULATION COMPRISING AN OUTERLAYER WITH AN ENZYMATICYALLY DEGRADABLE POLYMER, ITS COMPOSITION AND ITS METHOD OF MANUFACTURING
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机译:延迟释放药物制剂,其包含外层具有酶可降解的聚合物,其组合物及其制造方法
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摘要
A method of producing a coatable core for a delayed release drug formulation for oral administration to deliver a drug to the colon. The method comprises forming a core comprising a drug. An outer layer coating preparation is formed by combining a first aqueous preparation of an enzymatically degradable polymer which is degradable by colonic bacterial enzymes; a second aqueous preparation of a film-forming enteric polymer having a pH threshold of about pH 6 or above; and an organic anti-tack agent. The core is then coated with the outer layer coating preparation to form an outer layer coated core.
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