Evaluation of the effect of polymer content on drug release and mechanical strength of a Geopolymer ER Formulation for opioid drugs

摘要

The study showed that the enteric coating polymer reduced the drug release rate at pH 1 but increased release rate at pH condition similar to the small intestine. Although, the polymer content influenced the compressive strength of the geopolymer formulation, the strength was still higher than the reference ER formulation. The results indicate the enteric coating polymer has potential as an excipient in geopolymer formulation to improve the drug release performances.