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IMMUNOSTIMULATORY COMPOSITIONS BASED ON LIPOSOMES WITH ZWITERIONIC AND CATIONIC LIPIDS
IMMUNOSTIMULATORY COMPOSITIONS BASED ON LIPOSOMES WITH ZWITERIONIC AND CATIONIC LIPIDS
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机译:基于血糖体和阳离子脂质的脂质体的免疫刺激组合物
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摘要
The invention relates to an immunostimulatory composition comprising a liposome-nucleic acid complex wherein said complex contains (1) a liposome which, in terms of its lipids, comprises or consists of a first lipid and a second lipid, wherein the first lipid is a zwitterionic lipid and the second lipid is a cationic lipid, and (2) one or more immunostimulatory oligonucleotides and/or one or more polynucleotides. The invention further relates to certain uses of the immunostimulatory composition and to methods for preparing the same. In particular, the invention concerns the use of a zwitterionic lipid in an immunostimulatory composition comprising a liposome-nucleic acid complex to induce type I interferon immune responses and/or to reduce or even bypass TLR-mediated immune responses.
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