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Automated exposition of known and novel multiple myeloma genomic variants using a single sequencing platform
Automated exposition of known and novel multiple myeloma genomic variants using a single sequencing platform
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机译:使用单个测序平台的已知和新型多发性骨髓瘤基因组变体的自动阐述
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摘要
A sequencing capture array for identifying mutations in Multiple Myeloma is disclosed. Also disclosed are targeted next generation sequencing methods for identifying SNV, CNV, and translocation mutations in Multiple Myeloma tumor cells. A capture array representing fewer than 500 genes implicated in Multiple Myeloma can be used to analyze tumor mutations and create a personalized treatment plan for a Multiple Myeloma patient. Analytical methods are presented that allow tumor mutations to be elucidated with coverage at a sequencing depth of no more than 500×, or as low as 100×, with optimal efficiency achieved at a sequencing depth of about 300×.
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