PREPARATION METHOD OF ARTIFICIALLY SYNTHESIZED RACEMIC NICOTINE AND ITS SALT

摘要

The present invention relates to a method for preparing an artificial synthetic racemic nicotine salt, and more particularly, to a method for preparing racemic nicotine and a salt thereof obtained through a two-step reaction from 4-methylamino-1-(3-pyridine)-butanone hydrochloride. will be. Specific synthetic steps include (1) dissolving 4-methylamino-1-(3-pyridine)-butanone hydrochloride in a suitable reaction vessel using a suitable solvent, and performing the reaction in a basic solution of an appropriate concentration and at an appropriate temperature condition; , after completion of the reaction, concentration and purification using an appropriate solvent to obtain 1-methyl-2-(3-pyridine)-2-pyrrolidinol; (2) In a reaction vessel, 1-methyl-2-(3-pyridine)-2-pyrrolidinol is reacted in a suitable solvent with an appropriate amount of a reducing agent and an appropriate temperature condition, and after the reaction is completed, the reaction is concentrated. Then, it is purified using a suitable solvent to obtain racemic nicotine of high content and high purity, and then reacted with an appropriate acid to obtain an artificial synthetic racemic nicotine salt. The method for preparing an artificial synthetic racemic nicotine salt provided by the present invention is simple, inexpensive, easy to operate, has mild reaction conditions, protects the environment, and is suitable for use in large-scale industrial production.