ENANTIOSELECTIVE CHEMOENZYMATIC SYNTHESIS OF (R)-GAMMA-VALEROLACTONE FROM LEVULINIC ACID

摘要

The present invention relates to a method for preparing R-type gamma valerolactone ((R)-γ-valerolactone), and by applying an enzyme-chemical reaction, selectivity and reaction yield for chiral purity of a target product can be increased. Compared to the reaction method using conventional chemical catalysts, it is safe because it does not use hydrogen gas (H 2 ) and high concentrations of acids/bases, it is environmentally friendly because it does not use organic solvents, and it reacts at room temperature so that energy consumption is low. The reaction can be carried out via a route. In addition, the reaction is simple by using levulinic acid itself without using a levulinic acid derivative such as levulinic acid ester as a reactant, and it is advantageous in terms of cost, time, and operation by omitting unnecessary reaction processes, By using the process of the present invention, since formic acid can be used for NADH regeneration in the first enzymatic reaction, by-products can be utilized rather than the separation process, thereby reducing costs.