Manufacturing method of patient-specific anticancer therapeutic agent and its therapeutic method

摘要

PROBLEM TO BE SOLVED: To provide a solution for identifying an antibody that provides the maximum benefit to a target patient so that treatment can be started as soon as possible while minimizing the time required for research. Obtained from a patient in a microfluidic device 100 having at least one flow region and at least one isolation chamber 124, 126, 128, 130 comprising a separation region fluidly connected to the flow region. At least one isolated by loading a dissociated cell sample from at least one solid tumor sample and moving at least one B cell from the dissociated cell sample to at least one isolation region of the microfluidic device. Produce antibodies capable of binding cancer cell-related antigens, including obtaining B cells and identifying at least one isolated B cell that produces antibodies capable of binding cancer cell-related antigens. A method for identifying isolated B cells. [Selection diagram] FIG. 1A