Carboxylic acid-type lipids and lipid particles and lipid membranes containing the carboxylic acid-type lipids

摘要

The present invention provides carboxylic acid-type lipids such as GPIb and H12, which are carboxylic acid-type lipids capable of promoting platelet adhesion or aggregation without supporting proteins or peptides involved in platelet adhesion or aggregation. A lipid particle containing, a lipid membrane containing the carboxylic acid type lipid, and a platelet aggregation promoter, a platelet adhesion promoter, a hemostatic agent containing the carboxylic acid type lipid, the lipid particle or the lipid membrane, and the like. A carboxylic acid-type lipid selected from carboxylic acid-type lipids represented by the formulas (I) to (VI), the carboxylic acid type lipid, in order to provide a platelet substitute and to achieve such an object. Lipid particles containing acid-type lipids, lipid membranes containing the carboxylic acid-type lipids, and platelet aggregation promoters and platelet adhesion promoters containing the carboxylic acid-type lipids, the lipid particles or the lipid membranes. , Hemostatic agents and lipid substitutes.