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METHODS AND COMPOSITIONS FOR TRACKING NUCLEIC ACID FRAGMENT ORIGIN FOR NUCLEIC ACID SEQUENCING
METHODS AND COMPOSITIONS FOR TRACKING NUCLEIC ACID FRAGMENT ORIGIN FOR NUCLEIC ACID SEQUENCING
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机译:用于跟踪核酸片段核酸测序的核酸片段源的方法和组合物
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摘要
The present disclosure provides methods and compositions for tracking nucleic acid fragment origin by target-specific barcode tagging when original nucleic acid targets break into small fragments. Nucleic acid targets are captured in vitro on a solid support with clonally localized nucleic acid barcode templates. Many nucleic acid targets canbe processed simultaneously in a massively parallel fashion without partition. These nucleic acid target tracking methods can be used for a variety of applications in both whole genome sequencing and targeted sequencing in order to accurately identify genomic variants, haplotype phasing and assembly, for example.
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