Method for diagnosing colorectal cancer based on metagenome and metabolome of extracellular vesicles

摘要

The present invention relates to a method for diagnosing colon cancer based on metagenome and metabolites of extracellular vesicles, and the method for diagnosing colorectal cancer according to the present invention includes metagenome analysis of extracellular vesicles secreted from intestinal bacteria and metabolites in extracellular vesicles. Through analysis, colorectal cancer can be diagnosed and predicted early, and bacteria-derived extracellular vesicles with significantly changed content in colorectal cancer and metabolites such as amino acids, amino alcohols, aromatic alcohols, carboxylic acids, and fatty acids are identified, and their By confirming the correlation and using it together as a biomarker, it is expected that the accuracy of colorectal cancer diagnosis can be improved, thereby lowering the incidence of colorectal cancer and enhancing the therapeutic effect.