Study on mechanism of Fructus mume in treatment of colorectal cancer based on network pharmacology method

摘要

Objective:To explore the key targets and mechanisms of action of Mume Fructus in the treatment of colorectal cancer based on network pharmacology.Methods:TCMSP database was adopted to screen the active components and potential targets of Mume Fructus.GeneCards and Disgest databases were used to collect disease targets for colorectal cancer.Cytoscape software was used to construct the component-target network diagram.STRING database was used to draw the PPI network.Finally,DAVID database was used to perform GO biological process analysis and KEGG pathway enrichment analysis of centre target proteins.Results:There were 58 potential targets for the treatment of colorectal cancer in Mume Fructus.The protein interaction network suggested that TP53、AKT1、MAPK8、JUN、EGF and TNF may be the core targets for the treatment of colorectal cancer in Mume Fructus.Gene ontology enrichment analysis showed 108 cellular biological processes,and KEGG pathway enrichment analysis showed 88 related signaling pathways,including p53,TNF,HIF-1 and so on.Conclusion:The treatment of colorectal cancer by Mume Fructus may be multi-target,multi-channel,and multi-level.This consequence may provide ideas and a basis for further research.