Microparticle for Bioanalytical Investigations and Method for Producing Such a Microparticle

摘要

The invention relaters to a microparticle for bioanalytical investigations and a method for its production. The microparticle is suitable for being transported through a flow cell of a flow cytometer in a fluid stream. The microparticle has a solid particle core and at least one nucleic acid sense biomolecule that is binding-specific for an antisense biomolecule. A layer composed of a water-soluble conjugate is arranged on the particle core, which layer includes at least one linear polymer and/or copolymer, which has at least one first group, by means of which the polymer and/or copolymer can be cross-linked by means of irradiation with an optical radiation having a discrete wavelength, has at least one second group, to which the at least one nucleic acid sense biomolecule is conjugated, and has at least one third group that is bound to the surface of the particle core by way of a functional linker group, wherein the linker group is not capable of binding to the at least one nucleic acid sense biomolecule.