COMPOSITIONS AND METHODS FOR COMBATING MULTIDRUG-RESISTANT BACTERIA

摘要

Provided are peptides, modified peptides, fragments thereof, conjugates thereof, and polymers thereof that have antibacterial activity against bacterial that include but are not limited to multidrug-resistant bacteria. In some embodiments, the presently disclosed subject matter relates to peptides that include the amino acid sequences RTVRCTCI (SEQ ID NO: 2), LSRTVRCTCISI (SEQ ID NO: 3) or VPLSRTVRCTCISI (SEQ ID NO: 4), PESK AIKNLLK AV SKERSKRSP (SEQ ID NO: 11), or KNLLK AV SKERSKRSP (SEQ ID NO: 12), modified peptides thereof, fragments thereof, and conjugates thereof, and any combination thereof. The peptides, modified peptides, fragments thereof, and conjugates thereof can be polymer-functionalized, encapsulated in a particle, embedded in and/or on a solid support, optionally wherein the peptide is formulated for release from the solid support, impregnated in a dressing, optionally wherein the peptide is formulated for release from the dressing, and/or is formulated for use in a nebulizer, for topical administration, and/or for systemic administration. Also provided are medical devices having a support layer with an antibacterial agent embedded therein or associated therewith, methods for inhibiting the growth of and/or killing bacteria, for recruiting immune cells to site of infection, for treating or preventing community and/or nosocomial infections, for inducing a subjects immune system against a pathogen, for treating bacterial infections present in wounds, for treating pulmonary infections, for treating or preventing systemic bacterial infections, and for combination therapies with conventional antibiotics.