KAT2B Use of KAT2B for the diagnosis of ciliary injury disease

摘要

The present invention relates to the use of KAT2B for the diagnosis of ciliary damage disease, and to a formulation for preventing or treating ciliary damage disease comprising KAT2B, wherein the biomarker KAT2B according to the present invention is alpha-tubulin (α-tubulin) in cilia. ) was confirmed to promote cilia formation by inducing acetylation, and the degree of acetylation of α-tubulin decreased in KAT2B knockdown and knockout, and IFT proteins and GLI1 By confirming that the expression level is reduced and a glomerular cyst is formed, KAT2B is proposed as a biomarker for the diagnosis of ciliary damage disease, and KAT2B protein is provided as a prophylactic or therapeutic agent for ciliary damage disease.