Use of ICK and KLC3 for the diagnosis of ciliary injury disease

摘要

The present invention relates to the use of ICK and KLC3 for the diagnosis of ciliary damage disease, and to a formulation for preventing or treating ciliary damage disease comprising a KLC3 inhibitor, ICK defect through knockout in the kidney of an animal model By confirming that cilia are damaged, cyst is formed, and KLC3 protein is increased, demonstrating that ICK defect and KLC3 increase are indicators of ciliary damage, we propose ICK and KLC3 as biomarkers for the diagnosis of ciliary damage disease. In addition, the present invention confirms that cysts formed by ICK defects in renal epithelial cells are improved by suppressing KLC3 protein, thereby providing an inhibitor of KLC3 protein activity or KLC3 mRNA expression as a prophylactic or therapeutic agent for ciliary damage disease do.