IL-2 CD80 PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING FUSION PROTEIN COMPRISING IL-2 PROTEIN AND CD80 PROTEIN AND ANTICANCER DRUG

摘要

The present invention provides a pharmaceutical composition for treating cancer comprising a fusion protein comprising an IL-2 protein and a CD80 protein and an anticancer agent as an active ingredient. An embodiment of the present invention, a fusion protein comprising a CD80 fragment, immunoglobulin Fc and IL-2 variant can activate immune cells such as natural killer cells, and at the same time control the immune cell regulatory activity of regulatory T cells. . In addition, when an anticancer agent is administered in combination with the fusion protein, cancer can be effectively inhibited, and a fusion protein including IL-2 protein and CD80 protein and a pharmaceutical composition comprising an anticancer agent as an active ingredient increase immune activity in the body. As it can be effectively used for cancer diseases, it has high potential for industrial application.